In another bowl add about a cup of Panko breadcrumbs.
In a medium bowl, mix flour, cornstarch, garlic powder, smoked paprika, salt and pepper. To the bowl add the hot sauce, egg, and buttermilk and whisk until you have a smooth batter. Add the shrimp to the bowl, toss to make sure each piece is coated in the batter and set aside.
Preheat oven to 400 F degrees. Line a baking sheet with parchment paper.